On May 16, 2025, Javier Milei canceled his trip to Rome for Pope León XIV's inauguration to support Manuel Adorni during the Buenos Aires legislative elections. Milei accompanied Adorni in Buenos Aires neighborhoods for campaign events, urging voters to support him; Argentina will be represented at the Vatican by Dr. Gerardo Werthein and Lic. Sandra Pettovello.

On May 18, 2025, Buenos Aires will hold legislative elections to renew 30 of the 60 seats in the local legislature. Over 2.5 million eligible voters will participate using the Boleta Única Electrónica (BUE) system, with voting centers open from 8 a.m. to 6 p.m.

As of May 15, 2025, voting is mandatory in Buenos Aires for Argentine citizens aged 18 to 70. Those aged 16-17 and over 70 can vote optionally, and foreigners residing in the city also have the right to vote; failure to vote without justification results in fines.

On May 16, 2025, internal divisions within La Libertad Avanza (LLA) surfaced regarding candidate lists for Buenos Aires. Santiago Caputo's digital team criticized Sebastián Pareja for omitting Agustín Romo in a photo of libertarian leadership, leading to further criticism from Daniel Parisini.

On May 16, 2025, it was reported that the use of synthetic drugs, especially ecstasy, is increasing at electronic music parties in Argentina. Techno festivals have returned to the youth scene after disappearing following the 2016 Time Warp tragedy.

On May 15, 2025, Ariel Castillo, 47, died in a San Martín hospital after being drugged and robbed by a "viudo negro" (black widow) he met on Tinder.

On May 15, 2025, a bus driver on Line 60 in Rincón de Milberg, Tigre, Buenos Aires, argued with a passenger, pulled out a knife, and chased him after recognizing him from a previous incident. The driver was suspended, and DOTA initiated an administrative investigation after the passenger asked the driver to stop insulting and open the door.

On May 15, 2025, Tomás Vaccarezza stated that pedophiles often contact children through games and social media, with children getting their first cell phone around age 9. In the past year, the National Center for Missing and Exploited Children sent 120,000 reports to Argentina regarding child sexual exploitation material, with approximately 2,200 originating from Buenos Aires.

On May 15, 2025, it was reported that the PRO party aims to retain 15 seats, Unión por la Patria seeks to renew 8 seats, and La Libertad Avanza will try to retain 6 seats in the upcoming Buenos Aires legislative election.

On May 15, 2025, during the election period in Buenos Aires, there were speculations that the government's measure was aimed at Nicolás Nicky Caputo, a Mirgor shareholder, to contain inflation and stabilize the exchange rate before the October elections.

On May 16, 2025, Guillermo Luis Bravo noted that the local elections for legislators in Buenos Aires have become very nationalized, with candidates addressing national issues.

On May 15, 2025, La Libertad Avanza candidate Manuel Adorni stated he would "win" the upcoming Buenos Aires legislative elections and praised the PRO party.

On May 15, 2025, electoral authorities advised voters in Buenos Aires to vote in the morning to avoid potential issues at closing time.

On May 15, 2025, it was reported that Article 26 of the Electoral Code of the City states that those who do not justify their absence from voting or pay the fine may face restrictions on public procedures and positions for 3 years.

On May 15, 2025, Manuel Adorni refuted claims that attendees at La Libertad Avanza's campaign event in Parque Mitre were promised $25,000 for chanting his and Javier Milei's names, attributing the claims to "infiltrators."

On May 14, 2025, at the PRO closing event for the elections in CABA, Jorge Macri stated that "the people of Buenos Aires do not deserve a leap into the void."

On May 14, 2025, Leandro Santoro closed his campaign at the UBA, stating, "What is being discussed here is Social, environmental and distributive Justice."

On May 15, 2025, Buenos Aires Minister of Economy Pablo López, along with ministers from Santa Fe and Chaco, warned that any fiscal reform must be coordinated, sustainable, and respect federalism, after Minister of Economy Luis Caputo asked provinces to lower taxes.

On May 16, 2025, a survey in Buenos Aires revealed high concern about inflation, with most people feeling the impact of rising prices despite the government celebrating a 2.8% inflation rate in April.

On May 15, 2025, the UTA and business representatives agreed to meet again on June 1, 2025, to assess salary updates.

On May 15, 2025, it was reported that Dante Mastropierro, known as El Negro Pablo from Stagnaro's "Okupas," opened a community dining hall in La Boca and wrote his autobiography after brief TV roles.

On May 16, 2025, Juan Enrique Salaverry recounted transporting electronic components from the Port of Buenos Aires to Ushuaia, discovering the cargo was replaced with cell phones labeled as "Made in A.A.E. Tierra del Fuego, Industria Argentina."

On May 15, 2025, it was announced that Valentina Olguín will perform at the Movistar Arena with singer Cardellino on June 14, 2025.

On May 15, 2025, Buenos Aires implemented measures to improve road safety, particularly in the Microcentro, including creating new motorcycle parking spaces.

On May 15, 2025, San Lorenzo's players stopped training due to unpaid salaries, despite the AFA depositing approximately US$ 650,000 into an embargoed club account, leading to discontent among players.